{"id":3782,"date":"2021-06-23T23:27:53","date_gmt":"2021-06-23T23:27:53","guid":{"rendered":"https:\/\/dccs.udd.cl\/?p=3782"},"modified":"2021-06-23T23:27:53","modified_gmt":"2021-06-23T23:27:53","slug":"frontoparietal-connectivity-correlates-with-working-memory-performance-in-multiple-sclerosis-2","status":"publish","type":"post","link":"https:\/\/gobierno.udd.cl\/doctorate\/2021\/06\/23\/frontoparietal-connectivity-correlates-with-working-memory-performance-in-multiple-sclerosis-2\/","title":{"rendered":"Frontoparietal connectivity correlates with working memory performance in multiple sclerosis"},"content":{"rendered":"<p>Figueroa-Vargas, A., C\u00e1rcamo, C., Henr\u00edquez-Ch, R., Zamorano, F., Ciampi, E., Uribe-San-Martin, R., &#8230; &amp; Billeke, P. (2020). Frontoparietal connectivity correlates with working memory performance in multiple sclerosis. Scientific Reports, 10(1), 1-13.<\/p>\n<p><strong>Abstract<\/strong><\/p>\n<p>Working Memory (WM) impairment is the most common cognitive deficit of\u00a0patients with Multiple Sclerosis (MS). However, evidence of its neurobiological mechanisms is scarce. Here we recorded electroencephalographic activity of twenty patients with relapsing-remitting MS and minimal cognitive deficit, and 20 healthy control (HC) subjects while they solved a WM task. In spite of similar performance, the HC group demonstrated both a correlation between temporoparietal theta activity and memory load, and a correlation between medial frontal theta activity and successful memory performances. MS patients did not show theses correlations leading significant differences between groups. Moreover, cortical connectivity analyses using granger causality and phase-amplitude coupling between theta and gamma revealed that HC group, but not MS group, presented a load-modulated progression of the frontal-to-parietal connectivity. This connectivity correlated with working memory capacity in MS groups. This early alterations in the oscillatory dynamics underlaying working memory could be useful for plan therapeutic interventions.<\/p>\n<p>Read the paper <a href=\"https:\/\/www.nature.com\/articles\/s41598-020-66279-0\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>here<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Figueroa-Vargas, A., C\u00e1rcamo, C., Henr\u00edquez-Ch, R., Zamorano, F., Ciampi, E., Uribe-San-Martin, R., &#8230; &amp; Billeke, P. (2020). Frontoparietal connectivity correlates with working memory performance in multiple sclerosis. Scientific Reports, 10(1), 1-13. Abstract Working Memory (WM) impairment is the most common cognitive deficit of\u00a0patients with Multiple Sclerosis (MS). However, evidence of its neurobiological mechanisms is scarce. [&hellip;]<\/p>\n","protected":false},"author":0,"featured_media":3698,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-3782","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-publications"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Frontoparietal connectivity correlates with working memory performance in multiple sclerosis - Doctoral Program in Social Complexity Sciences<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/gobierno.udd.cl\/doctorate\/2021\/06\/23\/frontoparietal-connectivity-correlates-with-working-memory-performance-in-multiple-sclerosis-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Frontoparietal connectivity correlates with working memory performance in multiple sclerosis - Doctoral Program in Social Complexity Sciences\" \/>\n<meta property=\"og:description\" content=\"Figueroa-Vargas, A., C\u00e1rcamo, C., Henr\u00edquez-Ch, R., Zamorano, F., Ciampi, E., Uribe-San-Martin, R., &#8230; &amp; Billeke, P. (2020). Frontoparietal connectivity correlates with working memory performance in multiple sclerosis. Scientific Reports, 10(1), 1-13. Abstract Working Memory (WM) impairment is the most common cognitive deficit of\u00a0patients with Multiple Sclerosis (MS). However, evidence of its neurobiological mechanisms is scarce. 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