Background
\nPeople with schizophrenia show social impairments that are related to functional outcomes. We tested the hypothesis that social interaction impairments in people with schizophrenia are related to alterations in the predictions of others\u2019 behavior and explored their underlying neurobiological mechanisms.<\/p>\n
Methods
\nElectroencephalography was performed in 20 patients with schizophrenia and 25 well-matched control subjects. Participants played as proposers in the repeated version of the Ultimatum Game believing that they were playing with another human or with a computer. The power of oscillatory brain activity was obtained by means of the wavelet transform. We performed a trial-by-trial correlation between the oscillatory activity and the risk of the offer.<\/p>\n
Results
\nControl subjects adapted their offers when playing with computers and tended to maintain their offers when playing with humans, as such revealing learning and bargaining strategies, respectively. People with schizophrenia presented the opposite pattern of behavior in both games. During the anticipation of others\u2019 responses, the power of alpha oscillations correlated with the risk of the offers made, in a different way in both games. Patients with schizophrenia presented a greater correlation in computer games than in human games; control subjects showed the opposite pattern. The alpha activity correlated with positive symptoms.<\/p>\n
Conclusions
\nOur results reveal an alteration in social interaction in patients with schizophrenia that is related to oscillatory brain activity, suggesting maladjustment of expectation when patients face social and nonsocial agents. This alteration is related to psychotic symptoms and could guide further therapies for improving social functioning in patients with schizophrenia.<\/p>\n
P. Billeke, A. Armijo, D. Castillo, T. L\u00f3pez, F. Zamorano, D. Cosmelli y F. Aboitiz. Biological Psychiatry. DOI:\u00a010.1016\/j.biopsych.2015.02.012. ABSTRACT Background People with schizophrenia show social impairments that are related to functional outcomes. We tested the hypothesis that social interaction impairments in people with schizophrenia are related to alterations in the predictions of others\u2019 behavior and […]<\/p>\n","protected":false},"author":9192218,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9,5],"tags":[],"class_list":["post-2240","post","type-post","status-publish","format-standard","hentry","category-papers","category-publications"],"yoast_head":"\n![\"PDF\"](\"https:\/\/gobierno.udd.cl\/cics\/files\/2012\/07\/pdf-cics.jpg\")
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