{"id":1656,"date":"2014-01-10T20:17:30","date_gmt":"2014-01-10T20:17:30","guid":{"rendered":"http:\/\/www.complejidadsocial.udd.cl\/?p=1656"},"modified":"2014-01-10T20:17:30","modified_gmt":"2014-01-10T20:17:30","slug":"neural-progenitors-patterning-and-ecology-in-neocortical-origins","status":"publish","type":"post","link":"https:\/\/gobierno.udd.cl\/cics\/2014\/01\/10\/neural-progenitors-patterning-and-ecology-in-neocortical-origins\/","title":{"rendered":"Neural progenitors, patterning and ecology in neocortical origins"},"content":{"rendered":"<p>Francisco Aboitiz and Francisco Zamorano. Frontiers in Neuroanatomy. 01\/2013; 7:38. DOI:10.3389\/fnana.2013.00038.<\/p>\n<p><strong>ABSTRACT<\/strong><\/p>\n<p>The anatomical organization of the mammalian neocortex stands out among vertebrates for its laminar and columnar arrangement, featuring vertically oriented, excitatory pyramidal neurons. The evolutionary origin of this structure is discussed here in relation to the brain organization of other amniotes, i.e., the sauropsids (reptiles and birds). Specifically, we address the developmental modifications that had to take place to generate the neocortex, and to what extent these modifications were shared by other amniote lineages or can be considered unique to mammals. In this article, we propose a hypothesis that combines the control of proliferation in neural progenitor pools with the specification of regional morphogenetic gradients, yielding different anatomical results by virtue of the differential modulation of these processes in each lineage. Thus, there is a highly conserved genetic and developmental battery that becomes modulated in different directions according to specific selective pressures. In the case of early mammals, ecological conditions like nocturnal habits and reproductive strategies are considered to have played a key role in the selection of the particular brain patterning mechanisms that led to the origin of the neocortex.<\/p>\n<p><a href=\"https:\/\/gobierno.udd.cl\/cics\/files\/2014\/01\/Aboitiz-Zamorano-2013-Neural-progenitors-patterning-and-ecology-in-neocortical-origins.pdf\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-85\" src=\"https:\/\/gobierno.udd.cl\/cics\/files\/2012\/07\/pdf-cics.jpg\" alt=\"PDF\" width=\"40\" height=\"40\" \/><\/a><\/p>\n<p id=\"yui_3_10_0_1_1389181527856_2120\">Do not disseminate\/print without permission of copyright holder.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Francisco Aboitiz and Francisco Zamorano. Frontiers in Neuroanatomy. 01\/2013; 7:38. DOI:10.3389\/fnana.2013.00038. ABSTRACT The anatomical organization of the mammalian neocortex stands out among vertebrates for its laminar and columnar arrangement, featuring vertically oriented, excitatory pyramidal neurons. The evolutionary origin of this structure is discussed here in relation to the brain organization of other amniotes, i.e., the [&hellip;]<\/p>\n","protected":false},"author":9192218,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9,5],"tags":[],"class_list":["post-1656","post","type-post","status-publish","format-standard","hentry","category-papers","category-publications"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Neural progenitors, patterning and ecology in neocortical origins - Centro de Investigaci\u00f3n en Complejidad Social<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/gobierno.udd.cl\/cics\/2014\/01\/10\/neural-progenitors-patterning-and-ecology-in-neocortical-origins\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Neural progenitors, patterning and ecology in neocortical origins - Centro de Investigaci\u00f3n en Complejidad Social\" \/>\n<meta property=\"og:description\" content=\"Francisco Aboitiz and Francisco Zamorano. Frontiers in Neuroanatomy. 01\/2013; 7:38. DOI:10.3389\/fnana.2013.00038. ABSTRACT The anatomical organization of the mammalian neocortex stands out among vertebrates for its laminar and columnar arrangement, featuring vertically oriented, excitatory pyramidal neurons. The evolutionary origin of this structure is discussed here in relation to the brain organization of other amniotes, i.e., the [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/gobierno.udd.cl\/cics\/2014\/01\/10\/neural-progenitors-patterning-and-ecology-in-neocortical-origins\/\" \/>\n<meta property=\"og:site_name\" content=\"Centro de Investigaci\u00f3n en Complejidad Social\" \/>\n<meta property=\"article:published_time\" content=\"2014-01-10T20:17:30+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/gobierno.udd.cl\/cics\/files\/2012\/07\/pdf-cics.jpg\" \/>\n<meta name=\"author\" content=\"mariapia.kralemann\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"mariapia.kralemann\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/gobierno.udd.cl\/cics\/2014\/01\/10\/neural-progenitors-patterning-and-ecology-in-neocortical-origins\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/gobierno.udd.cl\/cics\/2014\/01\/10\/neural-progenitors-patterning-and-ecology-in-neocortical-origins\/\"},\"author\":{\"name\":\"mariapia.kralemann\",\"@id\":\"https:\/\/gobierno.udd.cl\/cics\/#\/schema\/person\/129ad217f6071913cdd7514153362439\"},\"headline\":\"Neural progenitors, patterning and ecology in neocortical origins\",\"datePublished\":\"2014-01-10T20:17:30+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/gobierno.udd.cl\/cics\/2014\/01\/10\/neural-progenitors-patterning-and-ecology-in-neocortical-origins\/\"},\"wordCount\":210,\"commentCount\":0,\"image\":{\"@id\":\"https:\/\/gobierno.udd.cl\/cics\/2014\/01\/10\/neural-progenitors-patterning-and-ecology-in-neocortical-origins\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/gobierno.udd.cl\/cics\/files\/2012\/07\/pdf-cics.jpg\",\"articleSection\":[\"PAPERS\",\"PUBLICATIONS\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/gobierno.udd.cl\/cics\/2014\/01\/10\/neural-progenitors-patterning-and-ecology-in-neocortical-origins\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/gobierno.udd.cl\/cics\/2014\/01\/10\/neural-progenitors-patterning-and-ecology-in-neocortical-origins\/\",\"url\":\"https:\/\/gobierno.udd.cl\/cics\/2014\/01\/10\/neural-progenitors-patterning-and-ecology-in-neocortical-origins\/\",\"name\":\"Neural progenitors, patterning and ecology in neocortical origins - 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