{"id":133,"date":"2007-05-24T03:10:16","date_gmt":"2007-05-24T03:10:16","guid":{"rendered":"http:\/\/www.complejidadsocial.udd.cl\/?p=133"},"modified":"2007-05-24T03:10:16","modified_gmt":"2007-05-24T03:10:16","slug":"the-evolution-of-developmental-patterning-under-genetic-duplication-constraints","status":"publish","type":"post","link":"https:\/\/gobierno.udd.cl\/cics\/2007\/05\/24\/the-evolution-of-developmental-patterning-under-genetic-duplication-constraints\/","title":{"rendered":"The evolution of developmental patterning under genetic duplication constraints"},"content":{"rendered":"<p>Miguel Angel Fuentes and David C. Krakauer. J. R. Soc. Interface,\u00a0 doi:10.1098\/rsif.2007.1074, 2007.<\/p>\n<p><strong>ABSTRACT<\/strong><\/p>\n<p>Of considerable interest are the evolutionary and developmental origins of complex, adaptive structures and the mechanisms that stabilize these structures. We consider the relationship between the evolutionary process of gene duplication and deletion and the stability of morphogenetic patterns produced by interacting activators and inhibitors. We compare the relative stability of patterns with a single activator and inhibitor (two-dimensional system) against a \u2018redundant\u2019 system with two activators or two inhibitors (three-dimensional system). We find that duplication events can both expand and contract the space of patterns.<\/p>\n<p>We study developmental robustness in terms of stochastic escape times from this space, also known as a \u2018canalization potential\u2019. We embed the output of pattern formation into an explicit evolutionary model of gene duplication, gene loss and variation in the steepness of the canalization potential. We find that under all constant conditions, the system evolves towards a preference for steep potentials associated with low phenotypic variability and longer lifespans. This preference leads to an overall decrease in the density of redundant genotypes as developmental robustness neutralizes the advantages of genetic robustness.<\/p>\n<p><a href=\"https:\/\/gobierno.udd.cl\/cics\/files\/2012\/05\/2007_TheEvolutionofDevelopmentalPatterningUnderGeneticDuplicationConstraints.pdf\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-85\" title=\"PDF\" src=\"https:\/\/gobierno.udd.cl\/cics\/files\/2012\/07\/pdf-cics.jpg\" alt=\"\" width=\"40\" height=\"40\" \/><\/a><\/p>\n<p><span style=\"font: 13px\/19.5px Arial, Verdana, sans-serif; text-align: left; color: #333333; text-transform: none; text-indent: 0px; letter-spacing: normal; word-spacing: 0px; float: none; display: inline !important; white-space: normal; background-color: #ffffff; -webkit-text-stroke-width: 0px;\">Do not disseminate\/print without permission of copyright holder.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Miguel Angel Fuentes and David C. Krakauer. J. R. Soc. Interface, 2007, doi:10.1098\/rsif.2007.1074.<\/p>\n","protected":false},"author":9192217,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9,5],"tags":[148,180,181,208,319],"class_list":["post-133","post","type-post","status-publish","format-standard","hentry","category-papers","category-publications","tag-development","tag-evodevo","tag-evolution","tag-genetics","tag-pattern-formation"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The evolution of developmental patterning under genetic duplication constraints - Centro de Investigaci\u00f3n en Complejidad Social<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/gobierno.udd.cl\/cics\/2007\/05\/24\/the-evolution-of-developmental-patterning-under-genetic-duplication-constraints\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The evolution of developmental patterning under genetic duplication constraints - Centro de Investigaci\u00f3n en Complejidad Social\" \/>\n<meta property=\"og:description\" content=\"Miguel Angel Fuentes and David C. Krakauer. J. R. Soc. Interface, 2007, doi:10.1098\/rsif.2007.1074.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/gobierno.udd.cl\/cics\/2007\/05\/24\/the-evolution-of-developmental-patterning-under-genetic-duplication-constraints\/\" \/>\n<meta property=\"og:site_name\" content=\"Centro de Investigaci\u00f3n en Complejidad Social\" \/>\n<meta property=\"article:published_time\" content=\"2007-05-24T03:10:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/gobierno.udd.cl\/cics\/files\/2012\/07\/pdf-cics.jpg\" \/>\n<meta name=\"author\" content=\"jhc\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"jhc\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/gobierno.udd.cl\/cics\/2007\/05\/24\/the-evolution-of-developmental-patterning-under-genetic-duplication-constraints\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/gobierno.udd.cl\/cics\/2007\/05\/24\/the-evolution-of-developmental-patterning-under-genetic-duplication-constraints\/\"},\"author\":{\"name\":\"jhc\",\"@id\":\"https:\/\/gobierno.udd.cl\/cics\/#\/schema\/person\/5b76ef104bf8776a2926aa964b447806\"},\"headline\":\"The evolution of developmental patterning under genetic duplication constraints\",\"datePublished\":\"2007-05-24T03:10:16+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/gobierno.udd.cl\/cics\/2007\/05\/24\/the-evolution-of-developmental-patterning-under-genetic-duplication-constraints\/\"},\"wordCount\":209,\"commentCount\":0,\"image\":{\"@id\":\"https:\/\/gobierno.udd.cl\/cics\/2007\/05\/24\/the-evolution-of-developmental-patterning-under-genetic-duplication-constraints\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/gobierno.udd.cl\/cics\/files\/2012\/07\/pdf-cics.jpg\",\"keywords\":[\"Development\",\"Evodevo\",\"Evolution\",\"Genetics\",\"Pattern formation\"],\"articleSection\":[\"PAPERS\",\"PUBLICATIONS\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/gobierno.udd.cl\/cics\/2007\/05\/24\/the-evolution-of-developmental-patterning-under-genetic-duplication-constraints\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/gobierno.udd.cl\/cics\/2007\/05\/24\/the-evolution-of-developmental-patterning-under-genetic-duplication-constraints\/\",\"url\":\"https:\/\/gobierno.udd.cl\/cics\/2007\/05\/24\/the-evolution-of-developmental-patterning-under-genetic-duplication-constraints\/\",\"name\":\"The evolution of developmental patterning under genetic duplication constraints - 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