{"id":1203,"date":"2013-05-10T19:45:32","date_gmt":"2013-05-10T19:45:32","guid":{"rendered":"http:\/\/www.complejidadsocial.udd.cl\/?p=1203"},"modified":"2013-05-10T19:45:32","modified_gmt":"2013-05-10T19:45:32","slug":"the-organization-and-evolution-of-the-protein-genotype-phenotype-map-evandro-ferradas-lectue","status":"publish","type":"post","link":"https:\/\/gobierno.udd.cl\/cics\/2013\/05\/10\/the-organization-and-evolution-of-the-protein-genotype-phenotype-map-evandro-ferradas-lectue\/","title":{"rendered":"&#8220;The organization and evolution of the protein genotype-phenotype map&#8221; Evandro Ferrada&#8217;s Lecture"},"content":{"rendered":"<p><a href=\"https:\/\/gobierno.udd.cl\/cics\/files\/2013\/05\/Evandro_Ferrada_udd_mayo2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-1216\" src=\"https:\/\/gobierno.udd.cl\/cics\/files\/2013\/05\/Evandro_Ferrada_udd_mayo2-650x1057.jpg\" alt=\"Evandro_Ferrada_udd_mayo\" width=\"650\" height=\"1057\" \/><\/a><\/p>\n<p><strong>Evandro Ferrada\u00a0<\/strong>holds a Ph.D. in evolutionary biology from the University of Zurich and a professional title in biochemistry from the Universidad Cat\u00f3lica de Chile. He attended <a href=\"http:\/\/www.santafe.edu\/education\/schools\/\" target=\"_blank\" rel=\"noopener noreferrer\">SFI\u2019s Complex Systems Summer School<\/a> in Argentina in 2008. He currently is an <a href=\"http:\/\/www.santafe.edu\/omidyar-fellowship\/\" target=\"_blank\" rel=\"noopener noreferrer\">Omidyar Fellow<\/a> from the Santa Fe Institute.<\/p>\n<p><b>Lecture:\u00a0 &#8220;The organization and evolution of the protein genotype-phenotype map&#8221;<\/b><\/p>\n<p><b>When:<\/b> Tuesday, 14th May, 11:30 hrs.<\/p>\n<p><b>Where<\/b>: Sala Penal, Universidad del Desarrollo, campus Rector Ernesto Silva Bafalluy, Av. La Plaza 680, Las Condes.<\/p>\n<p><b>Language:<\/b> Spanish (questions and commentaries in English are very welcome).<\/p>\n<p><strong>Abstract:<\/strong> The hierarchical process of biological development can be encapsulated by the idea of a mapping between genetic information (i.e. genotype) and form (i.e. phenotype). The simplest examples of genotype-phenotype maps are macromolecular systems such as the relation between sequence and structure in RNA and proteins, or the collection of enzymes and metabolites of a metabolic network. The organization of the map between genotypes and phenotypes provides important information on the dynamics and constraints operating on the evolutionary process of these systems. For instance, the number of similar sequences that fold onto a given structure provides information on both, the structure\u2019s robustness to mutations and its ability to evolve other phenotypes. In this talk I will elaborate on our current knowledge of the genotype-phenotype map of proteins. I will describe the main properties of this map and the seemingly unrelated ideas from different fields that have shed light on its organization and evolution.<\/p>\n<p><strong>Poster:<br \/>\n<a href=\"https:\/\/gobierno.udd.cl\/cics\/files\/2013\/05\/Evandro_Ferrada_udd_mayo.pdf\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-85\" src=\"https:\/\/gobierno.udd.cl\/cics\/files\/2012\/07\/pdf-cics.jpg\" alt=\"PDF\" width=\"40\" height=\"40\" \/><\/a><\/strong><\/p>\n<p><a href=\"http:\/\/www.santafe.edu\/about\/people\/profile\/Evandro%20Ferrada\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>More informati\u00f3n about Evandro Ferrada<\/strong><\/a><\/p>\n<p>This lecture is part of the activities of the proyject &#8220;Anillo en Complejidad Social&#8221; SOC-1101, PIA- CONICYT.<\/p>\n<p>[expand title=&#8221;ESPA\u00d1OL&#8221;]<\/p>\n<p><strong>Evandro Ferrada<\/strong> tiene un doctorado en\u00a0 biolog\u00eda evolutiva de la Universidad de Zurich y un t\u00edtulo profesional en bioqu\u00edmica de la Universidad Cat\u00f3lica de Chile. Asisti\u00f3 a la <a href=\"http:\/\/www.santafe.edu\/education\/schools\/\" target=\"_blank\" rel=\"noopener noreferrer\">Escuela de Verano de Sistemas Complejos de SFI <\/a>en Argentina en 2008. En la actualidad es\u00a0<a href=\"http:\/\/www.santafe.edu\/omidyar-fellowship\/\" target=\"_blank\" rel=\"noopener noreferrer\"><em>Omidyar Fellow<\/em>\u00a0<\/a>del Instituto de Santa Fe.<\/p>\n<p><strong>Charla: &#8220;Organizaci\u00f3n y evoluci\u00f3n del mapa genotipo-fenotipo de la prote\u00edna&#8221;<\/strong><\/p>\n<p><strong>Cu\u00e1ndo: <\/strong>martes 14 de mayo, 11:30 hrs.<\/p>\n<p><strong>D\u00f3nde: \u00a0<\/strong>Sala Penal, Universidad del Desarrollo, campus Rector Ernesto Silva Bafalluy, Av. La Plaza 680, Las Condes.<\/p>\n<p><strong>Idioma:<\/strong> Espa\u00f1ol (preguntas y comentarios en ingl\u00e9s son bienvenidos)<\/p>\n<p><strong>Resumen:<\/strong> El proceso jer\u00e1rquico de desarrollo biol\u00f3gico puede ser encapsulado por la idea de un mapeo entre la informaci\u00f3n gen\u00e9tica (es decir, el genotipo) y la forma (es decir fenotipo). Los ejemplos m\u00e1s simples de mapas genotipo-fenotipo son sistemas macromoleculares tales como la relaci\u00f3n entre la secuencia y estructura de ARN y prote\u00ednas, o\u00a0la colecci\u00f3n\u00a0de enzimas y metabolitos de una red metab\u00f3lica. La organizaci\u00f3n del mapa entre los genotipos y fenotipos ofrece informaci\u00f3n importante sobre la din\u00e1mica y las restricciones operativas en el proceso evolutivo de estos sistemas. Por ejemplo, el n\u00famero de secuencias similares que se pliegan en una estructura dada proporcionan informaci\u00f3n sobre ambas, la robustez de la estructura a mutaciones y su capacidad de evolucionar otros fenotipos. En esta charla me extender\u00e9 en nuestro conocimiento actual del mapa genotipo-fenotipo de las prote\u00ednas.\u00a0Describir\u00e9 las principales caracter\u00edsticas de este mapa y las ideas aparentemente inconexas de diferentes \u00e1mbitos que han arrojado luz sobre su organizaci\u00f3n y evoluci\u00f3n.<\/p>\n<p><strong>P\u00f3ster:<\/strong><br \/>\n<a href=\"https:\/\/gobierno.udd.cl\/cics\/files\/2013\/05\/Evandro_Ferrada_udd_mayo.pdf\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-85\" src=\"https:\/\/gobierno.udd.cl\/cics\/files\/2012\/07\/pdf-cics.jpg\" alt=\"PDF\" width=\"40\" height=\"40\" \/><\/a><\/p>\n<p><a href=\"http:\/\/www.santafe.edu\/about\/people\/profile\/Evandro%20Ferrada\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>M\u00e1s informaci\u00f3n sobre Evandro Ferrada<\/strong><\/a><\/p>\n<p>Esta charla es parte de las actividades del proyecto\u00a0&#8220;Anillo en Complejidad Social&#8221; SOC-1101, PIA- CONICYT.<\/p>\n<p>[\/expand]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Evandro Ferrada\u00a0holds a Ph.D. in evolutionary biology from the University of Zurich and a professional title in biochemistry from the Universidad Cat\u00f3lica de Chile. He attended SFI\u2019s Complex Systems Summer School in Argentina in 2008. He currently is an Omidyar Fellow from the Santa Fe Institute. Lecture:\u00a0 &#8220;The organization and evolution of the protein genotype-phenotype [&hellip;]<\/p>\n","protected":false},"author":9192218,"featured_media":2743,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,2,3],"tags":[],"class_list":["post-1203","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-calendar","category-events","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>&quot;The organization and evolution of the protein genotype-phenotype map&quot; Evandro Ferrada&#039;s Lecture - Centro de Investigaci\u00f3n en Complejidad Social<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/gobierno.udd.cl\/cics\/2013\/05\/10\/the-organization-and-evolution-of-the-protein-genotype-phenotype-map-evandro-ferradas-lectue\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"&quot;The organization and evolution of the protein genotype-phenotype map&quot; Evandro Ferrada&#039;s Lecture - Centro de Investigaci\u00f3n en Complejidad Social\" \/>\n<meta property=\"og:description\" content=\"Evandro Ferrada\u00a0holds a Ph.D. in evolutionary biology from the University of Zurich and a professional title in biochemistry from the Universidad Cat\u00f3lica de Chile. 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